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比利时vs摩洛哥足彩 ,
university of california san diego

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informal seminar on mathematics and biochemistry-biophysics

peter kekenes-huskey

university of kentucky, chemistry department

insight into molecular through subcellular calcium signaling via multi-scale simulation

abstract:

calcium is critical to a wide range of physiological processes, including neurological function, immune responses, and muscle contraction. calcium-dependent signaling pathways enlist a variety of proteins and channels that must rapidly and selectively bind calcium against thousand-fold higher cationic concentrations. frequently these pathways further require the co-localization of these proteins within specialized subcellular structures to function properly. our lab has developed multi-scale simulation tools to elucidate how protein structure and co-localization facilitate intracellular calcium signaling. developments include combining molecular simulations with a statistical mechanical model of ion binding, a homogenization theory to upscale molecular interactions into micron-scale diffusion models, and reaction-diffusion simulations that leverage sub-micron microscopy data. in this seminar, i will describe these tools and their applications toward molecular mechanisms of calcium-selective recognition and cross-talk between co-localized calcium binding proteins inside the cell.

hosts: li-tien cheng and bo li

may 19, 2016

2:00 pm

ap&m 5829

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